The Wales back division is unchanged for the third successive Six Nations game, with wing George North having shrugged off an ankle injury that meant he made an early exit against Scotland.
Alun-Wyn Jones, meanwhile, has not played Test rugby since the World Cup because of a toe injury, but he now returns to win his 60th cap.
“A fit-again Alun-Wyn Jones is selected based on his World Cup form and his experience as an international lock,” Wales coach Warren Gatland said.
“He gave us a selection dilemma, but it has been a great problem to have.
“While Ryan Jones is particularly unlucky to miss out on this occasion, this is just the kind of competition for places we have been striving for.
“Ken Owens has been waiting patiently for his chance and, while injuries elsewhere have meant he gets his opportunity this weekend, we are expecting him to take it.”
Ospreys hooker Richard Hibbard, who was called into Wales’ training squad two days ago, will provide bench cover for Owens.
A win for Wales would give them their 20th championship Triple Crown and leave them needing victory in two home games next month – against Italy and France – to secure a second Six Nations title and Grand Slam of Gatland’s four-year reign.
But they have only claimed one win at Twickenham since 1988 – a 26-19 success in 2008 that was Gatland’s first Test match in charge of Wales.
Wales team to play England in Saturday’s RBS 6 Nations clash at Twickenham (1600 kick-off):
L Halfpenny (Cardiff Blues) A Cuthbert (Cardiff Blues), J Davies (Scarlets), J Roberts (Cardiff Blues), G North (Scarlets); R Priestland (Scarlets), M Phillips (Bayonne); G Jenkins (Cardiff Blues), K Owens (Scarlets), A Jones (Ospreys), A-W Jones (Ospreys), I Evans (Ospreys), D Lydiate (Newport Gwent Dragons), S Warburton (Cardiff Blues, capt), T Faletau (Newport Gwent Dragons).
Replacements: R Hibbard (Ospreys), P James (Ospreys), R Jones (Ospreys), J Tipuric (Ospreys), L Williams (Cardiff Blues), J Hook (Perpignan), S Williams (Scarlets).